Methyl esters of trimethylammonium derivatives of polyene macrolide antibiotics.

Methyl esters of trimethylammonium derivatives of polyene macrolide antibiotics.

N-glycosyl derivatives of polyene macrolide antibiotics.

Sir: The polyene macrolides are known as potent antifungal agents. However their use in therapy is limited by considerable toxicity and very poor water solubility. Many efforts had been taken to obvert these undesirable properties1-5). We report now a new group of derivatives of polyene macrolides exhibiting improved solubility in water and organic solvents and retaining the biological activity...

The polyene macrolide antibiotics.

The mode of action of the polyene antibiotics is reviewed together with the effect of genetic and environmental factors on sensitive organisms. The future prospects of polyenes in the treatment of systemic mycoses are considered.

Hydrazides--a novel type of derivatives of polyene macrolide antifungal antibiotics.

properties ofpolyene macrolides wehave established the structure-activity relationship among the derivatives of amphotericin B, the polyene antibiotic most commonly used in clinical practice11}. It has been shown in these studies that the improvement of selective toxicity is related to the absence of a free carboxyl group in the modified antibiotic molecule. Wehave also demonstrated that water ...

Potentiation of antiviral activity of acyclovir by polyene macrolide antibiotics.

The potentiation of the antiviral activity of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] by polyene macrolide antibiotics has been studied as a function of the macrolide structure. The 12 polyenes chosen for this study represented the major structural groups of these antibiotics and induced in mammalian cells repairable membrane alterations or irreversible cell damage. The potentiating acti...